Diagnosing Lymphocytic Myocarditis in Adult Autopsies Combining the Dallas Criteria with Immunohistochemical Stainings

Diagnosing lymphocytic myocarditis in adult autopsies combining the Dallas criteria with immunohistochemical stainings

Aim: Endomyocardial biopsies form the golden standard in diagnosing (borderline) lymphocytic myocarditis ((B)LM) in living patients. Herein immunohistochemistry (IH) is mandatory. Diagnosing (B)-LM in autopsy hearts however is less defined. In this study we performed immunohistochemical stainings of heart slides in a cohort of consecutive adult autopsies that were evaluated subsequently with th...

Diagnosis of myocarditis: death of Dallas criteria.

Determining the etiology of cardiac dysfunction in patients with heart failure influences management and prognosis.1 Myocarditis, diagnosed by the current histopathological Dallas criteria, accounts for 10% of patients with new-onset cardiac dysfunction submitted to endomyocardial biopsy.1,2 Despite complete evaluation including history, physical examination, blood work, echocardiography, coron...

Giant Cell Versus Lymphocytic Myocarditis

Background. Giant cell myocarditis has rarely been diagnosed premortem, and little is known about its natural history. In addition, no comparative studies with lymphocytic myocarditis exist. Methods and Results. The clinical features, serial change in left ventricular fraction (LVEF), and outcomes of all patients with histologically verified myocarditis were retrospectively evaluated. Ten patie...

Lymphocytic myocarditis at autopsy in patients with dengue fever.

Recurrent lymphocytic myocarditis in a young male with ulcerative colitis

Awareness of myocarditis in association with inflammatory bowel diseases is crucial as it bears a rare but serious risk for mortality. This report describes the case of a young Caucasian male, whose heart biopsy was tested negative for giant cells and bacterial or viral genomes or proteins. He was experiencing severe lymphocytic myocarditis (other than mesalamine-induced) along with cardiogenic...